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Team publications

Scientific articles [2022]

  1. Fliedel L, Alhareth K, Mignet N, Fournier T, Andrieux K. Placental Models for Evaluation of Nanocarriers as Drug Delivery Systems for Pregnancy Associated Disorders. Biomedicines. 2022 Apr 19;10(5):936. Lien vers l’article >doi: 10.3390/biomedicines10050936.
  2. Al Sabbagh C, Agapova E, Boudy V, Mignet N. Stability of calcium levofolinate, 5-fluorouracil and oxaliplatin (FOLFOX) mixture. J Oncol Pharm Pract. 2022;28(6):1303-1314.  Lien vers l’article >doi: 10.1177/10781552211020808
  3. Rebollo R, Oyoun F, Corvis Y, El-Hammadi MM, Saubamea B, Andrieux K, Mignet N, Alhareth K. Microfluidic Manufacturing of Liposomes: Development and Optimization by Design of Experiment and Machine Learning. ACS Appl Mater Interfaces. 2022 Sep 7;14(35):39736-39745.  Lien vers l’article >doi: 10.1021/acsami.2c06627
  4. Do HD, Marie C, Bessoles S, Dhotel H, Seguin J, Larrat B, Doan BT, Scherman D, Escriou V, Hacein-Bey-Abina S, Mignet N. Combination of thermal ablation by focused ultrasound, pFAR4-IL-12 transfection and lipidic adjuvant provide a distal immune response. Explor Target Antitumor Ther. 2022;3(6):398-413. Lien vers l’article >doi: 10.37349/etat.2022.00090
  5.  Legrand P, Dembele O, Alamil H, Lamoureux C, Mignet N, Houzé P, Gahoual R. Structural identification and absolute quantification of monoclonal antibodies in suspected counterfeits using capillary electrophoresis and liquid chromatography-tandem mass spectrometry. Anal Bioanal Chem. 2022 Mar;414(8):2699-2712. Lien vers l’article > doi: 10.1007/s00216-022-03913-y
  6. Fliedel L, Alhareth K, Seguin J, El-Khashab M, Chissey A, Mignet N, Fournier T, Andrieux K. Influence of Liposomes’ and Lipoplexes’ Physicochemical Characteristics on Their Uptake Rate and Mechanisms by the Placenta. Int J Mol Sci. 2022 Jun 4;23(11):6299. Lien vers l’article > doi:10.3390/ijms23116299
  7.  Alviset G, Corvis Y, Hammad K, Lemut J, Maury M, Mignet N, Boudy V. New Preservative-Free Formulation for the Enhanced Ocular Bioavailability of Prostaglandin Analogues in Glaucoma. Pharmaceutics. 2022 Feb 20;14(2):453. Lien vers l’article > doi:10.3390/pharmaceutics14020453
  8.  Lécuyer T, Bia N, Burckel P, Loubat C, Graillot A, Seguin J, Corvis Y, Liu J, Valéro L, Scherman D, Mignet N, Richard C. Persistent luminescence nanoparticles functionalized by polymers bearing phosphonic acid anchors: synthesis, characterization, and in vivo behaviour. Nanoscale. 2022 Jan 27;14(4):1386-1394. Lien vers l’article > doi :10.1039/d1nr07114a
  9. Mhoumadi A, M. Elkashab, S. Prillieux, J.-B. Dumas, F. Collas, N. Louvain, B. Fraisse, P. Espeau. Characterization of the heat behavior of Amiodarone hydrochloride. Thermochim. Acta, 2022, 708, article 17912. Lien vers l’article > doi: : 110.1016/j.tca.2021.179121
  10. Corvis Y, Rosa F, Tran M-T, Renault G, Mignet N, Crauste-Manciet S, Espeau P. Thermal Analysis Tools for Physico-Chemical Characterization and Optimization of Perfluorocarbon Based Emulsions and Bubbles Formulated for Ultrasound Imaging. Colloids and Interfaces. 2022; 6(2):21. Lien vers l’article > doi:10.3390/colloids6020021
  11. Le Guyader G, Do B, Rietveld IB, Coric P, Bouaziz S, Guigner JM, Secretan PH, Andrieux K, Paul M. Mixed Polymeric Micelles for Rapamycin Skin Delivery. Pharmaceutics. 2022 Mar 4;14(3):569. Lien vers l’article > doi: 10.3390/pharmaceutics14030569

 

Review articles / literature reviews [2022]

  1. Difonzo , L. Fliedel , N. Mignet , K. Andrieux, K. Alhareth. How Could Nanomedicine Improve the Safety of Contrast Agents for MRI during Pregnancy? Sci 2022, 4, 11. Lien vers l’article > doi: 10.3390/sci4010011.
  2. Fliedel L, Alhareth K, Mignet N, Fournier T, Andrieux K. Placental Models for Evaluation of Nanocarriers as Drug Delivery Systems for Pregnancy Associated Disorders. Biomedicines. 2022 Apr 19;10(5):936. Lien vers l’article > doi: 10.3390/biomedicines10050936.
  3. Renault Mahieux, N. Mignet, J. Seguin, K. Alhareth, M. Paul, K. Andrieux. Co encapsulation of flavonoids with anti cancer drugs: a challenge ahead. International Journal of Pharmaceutics 2022, 63, 121942. Lien vers l’article > doi: 10.1016/j.ijpharm.2022.121942

Book chapters [2022]

  1. Fliedel L., Mignet N., Fournier T., Andrieux K. Quantification of a fluorescent lipid DOPE-NBD by an HPLC method in biological tissue: application to study liposome’s uptake by human placenta. In Liposomes: Methods and Protocols, volume 1522, in Methods in Molecular Biology (MiMB). 2022. Lien vers le livre
  2. Reinert T, Leize-Wagner E, Houzé P, Gahoual R, François Y-N. CE-MS methods for the characterization of monoclonal antibodies. Chap 11 Theoretical and practical application of CE-MS for biomolecules, 2022, in press (Elsevier).

Invited oral presentations [2022]

  1. Andrieux K. Development of lipoplexes for gene delivery for preeclampsia treatment. 5th NANOMED EMJMD Workshop “From biotechnology to nanobiotechnology and vaccines”, 11-13 July 2022, Pavia, Italy.
  2. Mignet N. Nanomedecine for imaging, International SymposPatents, licenses and invention declarationsiu on Radiopharceutical Science, IRCN 29 mai-2 juin 2022, Nantes
  3. Mignet N. Evolution technologique des nanomédecines, Journée Nanomédecine du LNE, Juin 2022
  4. Mignet N. Combinaison de méthodes physiques et de méthodes de délivrance, RITS, Brest, Mai 2022
  5. Mignet N. Combination of drug delivery systems and physical trigger to provide drug release or immunomodulation, CRS Indian Chapter, February 2022

Patents, licenses and invention declarations [2018-2022]

  1. Hang Korng EA, Vincent BOUDY, Amélie WOJCICKI, Sophie DUFAY. Alginate hydrogel and new composition derived therefrom for the treatment of ectopic calcifications. 2020-08-20 EP20305937.3; 2022-02-24 WO2022038213A1
  2. Pierre-Louis DESTRUEL, Vincent BOUDY, Ni ZENG, Nathalie MIGNET, Marc MAURY. Composition à base de gomme gellane et de phényléphrine, procédé de fabrication et utilisation comme produit ophtalmique. 2019-05-02 FRFR1904602; 2020-11-05 WO2020221839A1.
  3. Brice MARTIN, Nathalie MIGNET, Yohann CORVIS. Preparation of nanosuspension comprising nanocrystals of active pharmaceutical ingredients with little or no stabilising agents. 2018-08-27 EP18306138.1, 2020-03-05 WO2020043735A1.
  4. Yongmin ZHANG, Michel BESSODES, Johanne SEGUIN, Nathalie MIGNET, Daniel SCHERMAN. Agents d’imagerie optique ciblant une inflammation. 2018-02-21 EP18305183.8 ; 2019-08-29 WO2019162417A1.
  5. Hugo SALMON, Rabah GAHOUAL, Nathalie MIGNET, Pascal HOUZE. Dispositif microfluidique de fractionnement en continu à écoulement asymétrique et procédé d’utilisation correspondant 2018-02-22 EP 18305185.3, 2019-08-29 WO2019162404A1.
  6. Kathia LEMDANI, Johanne SEGUIN, Armand TIEDE DJIRO, Jean-Francois EMILE, Camille KURTZ, Nicolas LOMENIE. Procédé de détermination de l’infiltration de cellules biologiques dans un objet biologique. 2018-06-21 FR1855513A.
  7. Robert MALAFOSSE, Nathalie MIGNET, Vincent BOUDY, Johanne SEGUIN, Kathia LEMDANI, Claude CAPRON. Immunomodulation après un traitement antitumoral loco-régionale. 2016-08-31 EP16306102, 2018-03-08 WO2018041981A1
  8. Nathalie MIGNET, Bich-Thuy DOAN, Grégory RAMNICEANU, Olivier TILLEMENT, Lucie SANCEY GALLIOT, François LUX, Johanne SEGUIN. Nanoparticules ultrafines comme agent d’imagerie pour le diagnostic d’une dysfonction rénale. 2016-01-158, 2017-07-20 WO2017121858A1.
  9. Nathalie MIGNET, Vincent BOUDY, Johanne SEGUIN, Daniel SCHERMAN, Yoran BELDENGRUN. Compositions gélifiantes pour le traitement de tumeurs malignes et/ou la prévention de récidive de tumeur. 2015-09-166; 2017-03-23 WO2017046369A1.
  10. Stéphane AUVIN, Thomas STORME, Pascal VACONSIN, Vincent BOUDY. Formulation effervescente à base de pyridoxal-5-phosphate. 2015-06-30 FR1556142; 2017-01-05.
  11. Vincent BOUDY. Dispositif doseur de particules. 2013-07-17 FR1357012 ; 2015-01-22 WO2015008239A1.
  12. Vincent BOUDY, Annick TIBI, Benoît D’HAYER, Marie-Caroline HUSSON, Sandrine GRAFF DE FAGET ; Formulation gelifiante a base de ketamine. 2012-08-31 FR1258146, 2014-03-06 WO2014033680A1.
  13. Amanda BRUN-GRAEPPI, Daniel SCHERMAN, Michel BESSODES, Cyrille RICHARD, Otto MERTEN. Support pour la culture de cellules adhérentes et procédé pour leur détachement. 2012-08-17 EP 2698429 A1.
  14. Vincent BOUDY, Sandrine GRAFF DE FAGET, Caroline HUSSON, Imane BOUCENNA, Laurent ROYON, Pierre COLINART. Formulation gelifiante a base de gluconate de calcium. 2012-02-27 FR1251758, 2013-09-06 WO2013128383A1.

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