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Publications de l’équipe

Articles scientifiques 

2025

  1. J. Duffrène, C. Muzard, J. Seguin, C. Izabelle, T. Vrai, T. Ejlalmanesh, M. Bombled, S. Hamdi, K. Lemdani, K. Alhareth and N. Mignet. Post-encapsulation methods for the preparation of mRNA-LNPs. Drug Deliv Transl Res. 2025 May 6. doi: 10.1007/s13346-025-01866-0.
  2. K. Laguerre, M. Caillot, J. M. Casas-Solvas, A. Vargas-Berenguel, G.Urbinati*, R. Gref*. Gemcitabine-monophosphate encapsulation in “stealth” MOFs effectively inhibits tumor growth in vivo. Int.  J. Pharm., 2025, 675, 125537. doi: 10.1016/j.ijpharm.2025.125537

 2024

  1. M. Rassat, I. Ouandji, N. Guiblin, P. Espeau. Obtaining two polymorphic forms of paracetamol within the phase diagram with PEG 1500. Eur. J. Pharm. Biopharm., 2024, 195, 114173.
  2. V. Ianno, S. Vurpillot, S. Prillieux, P. Espeau. Pediatric Formulations Developed by Extrusion-Based 3D Printing: From Past Discoveries to Future Prospects.” . Pharmaceutics, 2024, 16, 441.
  3. Monica Swetha Bosco, Zeki Topçu, Soumen Pradhan, Ariadne Sossah, Vassilis Tsatsaris, Christelle Vauloup-Fellous, Sarit S. Agasti, Yves Rozenholc and Nathalie Gagey-Eilstein, A methodological study for the diagnosis of the SARS-Cov-2 infection in human serum with a macrocyclic sensor array, Sens. Diagn 2024, 3,863
  4. Yun Luo, Yu Xiao, Delphine Onidas, Laura Iannazzo, Mélanie Ethève-Quelquejeu, Aazdine Lamouri, Nordin Félidj, Samia Mahouche-Chergui, Thibault Brulé, Nathalie Gagey-Eilstein,  Florence Gazeau and  Claire Mangeney, Chem. Commun., 2020,56, 6822-6825
  5. Seguin J., El-Hajjam M., Legagneux J., Diakhaby S., Mignet N., Boudy V., Toussaint B., Peschaud F., Emile J-F., Capron C., Malafosse R., Radiofrequency combined to intratumoral immunotherapy: preclinical results and safety in metastatic colorectal carcinoma Pharmaceutics 2024, 16, 315, https:10.3390/pharmaceutics16030315
  6. Bahloul B., Ben Bnina E., Hamdi A., Castillo Henriquez L., Baccar D., Kalboussi N., Abbassi A., Mignet N., Flamini G., Vega-Baudrit J., Investigating the Wound Healing Potential of Nanoemulsion-Gel Formulation of Pituranthos tortuosus Essential Oil, Gels 2024,  10, 155, https://10.3390/gels10030155 .
  7. Reinert, T. Houzé P., François Y-N., Gahoual R., Enhancing affinity purification of monoclonal antibodies from human serum for subsequent CZE-MS analysis. J. Chrom. B, 2024, 1234, 123974. https://doi.org/10.1016/j.jchromb.2023.123974 
  8. Castillo Henríquez L, Bahloul B, Alhareth K, Oyoun F, Frejková M, Kostka L, Etrych T, Kalshoven L, Guillaume A, Mignet N, Corvis Y. Step-By-Step Standardization of the Bottom-Up semi-Automated Nanocrystallization of Pharmaceuticals: A Quality By Design and Design of Experiments Joint Approach.  Small. 2024 Feb 1:e2306054. doi: 10.1002/smll.202306054 
  9. Bahloul B, Chaabani R, Zahra Y, Kalboussi N, Kraiem J, Sfar S, Mignet N, Abdennebi HB. Thymoquinone-loaded self-nano-emulsifying drug delivery system against ischemia/reperfusion injury, Drug Deliv Transl Res. 2024 Jan;14(1):223-235. doi: 10.1007/s13346-023-01395-8.
  10. Zied Ferjaoui, Jianhua Liu, Daniel Scherman, Nathalie Mignet and Cyrille Richard. Improvement of Hydrogen Peroxide and Glucose Detection in Serum using Persistent Luminescent Nanoparticles: Impact of Synthesis Parameters and Particle Size. ChemNanoMat 2024, e202400078. doi.org/10.1002/cnma.202400078
  11. Guanyu Cai, Johanne Seguin, Thomas Naillon, Corinne Chanéac, Yohann Corvis, Daniel Scherman, Nathalie Mignet, Bruno Viana, Cyrille Richard. Chromium-doped zinc gallate: Impact of Sn4+ co-doping on the persistent luminescence properties at the nanoscale applied to bio-imaging. Chem Eng J 490 (2024) 151643.  doi.org/10.1016/j.cej.2024.151643
  12. Thouvenin A, Al Chirazi N, Seguin J, Crocheray C, Poupon J, Kaci R, Mignet N, Boudy V, Pocard M. Intraperitoneal administration of a thermogel combined with an anticancer agent for the prevention of peritoneal carcinomatosis in a pig model. Eur J Surg Oncol. 2024 Oct 28:108787. doi: 10.1016/j.ejso.2024.108787.

2023

  1. Liu J, Viana B, Mignet N, Scherman D, Liu Y, Richard C. H2 O2 -Induced Persistent Luminescence Signal Enhancement Applied to Biosensing. Small. 2023 Dec;19(49):e2303509. doi: 10.1002/smll.202303509
  2. Margarita López-Viota, Laura Martín-Pozo, Beatriz Parera, José Luis Vílchez, Julián L Viota, Khair Alhareth, Mazen M El-Hammadi. Varying coat properties of chitosan-surface modified polya (lactic-co-glycolic acid) nanoparticles for controlled delivery of 5-fluorouracil. Journal of Drug Delivery Science and Technology, 2023 Nov, 89: 104982. doi:1016/j.jddst.2023.104982.
  3. Vinck R, Dömötör O, Karges J, Jakubaszek M, Seguin J, Tharaud M, Guérineau V, Cariou K, Mignet N, Enyedy ÉA, Gasser G.In Situ Bioconjugation of a Maleimide-Functionalized Ruthenium-Based Photosensitizer to Albumin for Photodynamic Therapy. Inorg Chem. 2023 Sep 25;62(38):15510-15526. doi: 10.1021/acs.inorgchem.3c01984. 
  4. Renault-Mahieux M, Seguin J, Vieillard V, Le DT, Espeau P, Lai-Kuen R, Richard C, Mignet N, Paul M, Andrieux K.  Co-encapsulation of fisetin and cisplatin into liposomes: Stability considerations and in vivo efficacy on lung cancer animal model. Int J Pharm. 2023 Dec 23;651:123744. https://doi.org/10.1016/j.ijpharm.2023.123744
  5. Reinert T, Houzé P, Mignet N, Francois YN, Gahoual R. Post-translational modifications comparative identification and kinetic study of infliximab innovator and biosimilars in serum using capillary electrophoresis-tandem mass spectrometry.  J Pharm Biomed Anal. 2023 Sep 20;234:115541. https://doi.org/10.1016/j.jpba.2023.115541
  6. Reinert T, Gahoual R, Mignet N, Kulus A, Allez M, Houzé P, François YN. Simultaneous quantification and structural characterization of monoclonal antibodies after administration using capillary zone electrophoresis-tandem mass spectrometry.J Pharm Biomed Anal. 2023 Sep 5;233:115446. https://doi.org/10.1016/j.jpba.2023.115446
  7. Ma, P, Toussaint, B, Roberti, EA, Scornet, N, Santos Silva, A, Castillo Henríquez, L, Cadasse, M, Négrier,    P, Massip, S, Dufat, H, Hammad, K, Baraldi, C, Gamberini, MC, Richard, C, Veesler, S, Espeau, P, Lee, T, Corvis, Y. New Lidocaine-Based Pharmaceutical Cocrystals: Preparation, Characterization, and Influence of the Racemic vs. Enantiopure Coformer on the Physico-Chemical Properties. Pharmaceutics 2023, 15, 1102. https://doi.org/10.3390/pharmaceutics15041102.
  8. Lemercier, A, Couvrat, N, Cartigny, Y, Sanselme, M, Corvis, Y, Espeau, P, Coquerel, G. Evidence of a new crystalline phase of prednisolone obtained from the study of the hydration-dehydration mechanisms of the sesquihydrate. Pharmaceutics, 2023, 15, 1694. https://doi.org/10.3390/pharmaceutics15061694
  9. Toussaint B, Hassane Beck TI, Surget E, Jaccoulet E. Exploration of the effects of chloride ions on the analysis of polar compounds at low concentrations by hydrophilic interaction liquid chromatography coupled to as charged aerosol detector : application to tromethamine. J. Separation Sci. https://doi.org/10.1002/jssc.202200766
  10. Mattioni JB, de la Reberdiere C, Boudy V, Jaccoulet E Understanding the retention mechanisms of a reversed phase/anion exchange/cation-exchange column for the separation of epinephrine and norepinephrine. J. Pharm & Biomed. Anal 2023, https://doi.org/10.1016/j.jpba.2023.115273
  11. Legrand P, Dufaÿ S, Mignet N, Houzé P, Gahoual R. Modeling study of long-term stability of the monoclonal antibody infliximab and biosimilars using liquid-chromatography–tandem mass spectrometry and size-exclusion chromatography–multi-angle light scattering, Analytical and Bioanalytical Chemistry 415 (1), 179, https://10.1007/s00216-022-04396-7
  12. Cai G, Delgado T, Richard C, Viana C. ZGSO Spinel Nanoparticles with dual emission of NIR persistent luminescence for anti-counterfeit applications. Materials 2023, 16, 1132. https://doi.org/10.3390/ma16031132
  13. Giordano L, Cai G, Seguin J, Liu J, Richard C, Carvalho L, Rodrigues V, Viana C. ZGSO Spinel Nanoparticles with dual emission of NIR persistent luminescence for anti-counterfeit applications, Adv. Optical Materials 2023, 2201468, https://doi.org/10.1002/adom.202201468
  14. Larréché S, Bousquet A, Chevillard L, Gahoual R, Jourdi G, Dupart A-L, Bachelot-Loza C, Gaussem P, Siguret V, Chippaux J-P, Mégarbane B, Bothrops atrox and Bothrops lanceolatus Venoms In Vitro Investigation: Composition, Procoagulant Effects, Co-Factor Dependency, and Correction Using Antivenoms. Toxins, 2023, 15 (10), 614. https://doi.org/10.3390/toxins15100614
  15. Delphine Dassonville, Thomas Lécuyer, Johanne Seguin , Yohann Corvis , Jianhua Liu, Guanyu Cai, Julia Mouton, Daniel Scherman, Nathalie Mignet and Cyrille Richard. Coatings 2023, 13, 1913. org/10.3390/coatings13111913
  16. Guanyu Cai, Luidgi Giordano, Cyrille Richard, and Bruno Viana. Effect of the Elaboration Method on Structural and Optical Properties of Zn1.33Ga1.335Sn0.33O4:0.5%Cr3+ Persistent Luminescent Nanomaterials. Nanomaterials. Nanomaterials 2023, 13, 2175. https://doi.org/10.3390/nano13152175

2022

  1. Fliedel L, Alhareth K, Mignet N, Fournier T, Andrieux K. Placental Models for Evaluation of Nanocarriers as Drug Delivery Systems for Pregnancy Associated Disorders. Biomedicines. 2022 Apr 19;10(5):936. Lien vers l’article >doi: 10.3390/biomedicines10050936.
  2. Al Sabbagh C, Agapova E, Boudy V, Mignet N. Stability of calcium levofolinate, 5-fluorouracil and oxaliplatin (FOLFOX) mixture. J Oncol Pharm Pract. 2022;28(6):1303-1314.  Lien vers l’article >doi: 10.1177/10781552211020808
  3. Rebollo R, Oyoun F, Corvis Y, El-Hammadi MM, Saubamea B, Andrieux K, Mignet N, Alhareth K. Microfluidic Manufacturing of Liposomes: Development and Optimization by Design of Experiment and Machine Learning. ACS Appl Mater Interfaces. 2022 Sep 7;14(35):39736-39745.  Lien vers l’article >doi: 10.1021/acsami.2c06627
  4. Do HD, Marie C, Bessoles S, Dhotel H, Seguin J, Larrat B, Doan BT, Scherman D, Escriou V, Hacein-Bey-Abina S, Mignet N. Combination of thermal ablation by focused ultrasound, pFAR4-IL-12 transfection and lipidic adjuvant provide a distal immune response. Explor Target Antitumor Ther. 2022;3(6):398-413. Lien vers l’article >doi: 10.37349/etat.2022.00090
  5.  Legrand P, Dembele O, Alamil H, Lamoureux C, Mignet N, Houzé P, Gahoual R. Structural identification and absolute quantification of monoclonal antibodies in suspected counterfeits using capillary electrophoresis and liquid chromatography-tandem mass spectrometry. Anal Bioanal Chem. 2022 Mar;414(8):2699-2712. Lien vers l’article > doi: 10.1007/s00216-022-03913-y
  6. Fliedel L, Alhareth K, Seguin J, El-Khashab M, Chissey A, Mignet N, Fournier T, Andrieux K. Influence of Liposomes’ and Lipoplexes’ Physicochemical Characteristics on Their Uptake Rate and Mechanisms by the Placenta. Int J Mol Sci. 2022 Jun 4;23(11):6299. Lien vers l’article > doi:10.3390/ijms23116299
  7.  Alviset G, Corvis Y, Hammad K, Lemut J, Maury M, Mignet N, Boudy V. New Preservative-Free Formulation for the Enhanced Ocular Bioavailability of Prostaglandin Analogues in Glaucoma. Pharmaceutics. 2022 Feb 20;14(2):453. Lien vers l’article > doi:10.3390/pharmaceutics14020453
  8.  Lécuyer T, Bia N, Burckel P, Loubat C, Graillot A, Seguin J, Corvis Y, Liu J, Valéro L, Scherman D, Mignet N, Richard C. Persistent luminescence nanoparticles functionalized by polymers bearing phosphonic acid anchors: synthesis, characterization, and in vivo behaviour. Nanoscale. 2022 Jan 27;14(4):1386-1394. Lien vers l’article > doi :10.1039/d1nr07114a
  9. Mhoumadi A, M. Elkashab, S. Prillieux, J.-B. Dumas, F. Collas, N. Louvain, B. Fraisse, P. Espeau. Characterization of the heat behavior of Amiodarone hydrochloride. Thermochim. Acta, 2022, 708, article 17912. Lien vers l’article > doi: : 110.1016/j.tca.2021.179121
  10. Corvis Y, Rosa F, Tran M-T, Renault G, Mignet N, Crauste-Manciet S, Espeau P. Thermal Analysis Tools for Physico-Chemical Characterization and Optimization of Perfluorocarbon Based Emulsions and Bubbles Formulated for Ultrasound Imaging. Colloids and Interfaces. 2022; 6(2):21. Lien vers l’article > doi:10.3390/colloids6020021
  11. Le Guyader G, Do B, Rietveld IB, Coric P, Bouaziz S, Guigner JM, Secretan PH, Andrieux K, Paul M. Mixed Polymeric Micelles for Rapamycin Skin Delivery. Pharmaceutics. 2022 Mar 4;14(3):569. Lien vers l’article > doi: 10.3390/pharmaceutics14030569

 

Articles de synthèse / revues bibliographiques [2022]

  1. Difonzo , L. Fliedel , N. Mignet , K. Andrieux, K. Alhareth. How Could Nanomedicine Improve the Safety of Contrast Agents for MRI during Pregnancy? Sci 2022, 4, 11. Lien vers l’article > doi: 10.3390/sci4010011.
  2. Fliedel L, Alhareth K, Mignet N, Fournier T, Andrieux K. Placental Models for Evaluation of Nanocarriers as Drug Delivery Systems for Pregnancy Associated Disorders. Biomedicines. 2022 Apr 19;10(5):936. Lien vers l’article > doi: 10.3390/biomedicines10050936.
  3. Renault Mahieux, N. Mignet, J. Seguin, K. Alhareth, M. Paul, K. Andrieux. Co encapsulation of flavonoids with anti cancer drugs: a challenge ahead. International Journal of Pharmaceutics 2022, 63, 121942. Lien vers l’article > doi: 10.1016/j.ijpharm.2022.121942

Chapitres d’ouvrages [2022]

  1. Fliedel L., Mignet N., Fournier T., Andrieux K. Quantification of a fluorescent lipid DOPE-NBD by an HPLC method in biological tissue: application to study liposome’s uptake by human placenta. In Liposomes: Methods and Protocols, volume 1522, in Methods in Molecular Biology (MiMB). 2022. Lien vers le livre
  2. Reinert T, Leize-Wagner E, Houzé P, Gahoual R, François Y-N. CE-MS methods for the characterization of monoclonal antibodies. Chap 11 Theoretical and practical application of CE-MS for biomolecules, 2022, in press (Elsevier).

Communications orales invitées [2022]

  1. Andrieux K. Development of lipoplexes for gene delivery for preeclampsia treatment. 5th NANOMED EMJMD Workshop “From biotechnology to nanobiotechnology and vaccines”, 11-13 July 2022, Pavia, Italy.
  2. Mignet N. Nanomedecine for imaging, International Symposiu on Radiopharceutical Science, IRCN 29 mai-2 juin 2022, Nantes
  3. Mignet N. Evolution technologique des nanomédecines, Journée Nanomédecine du LNE, Juin 2022
  4. Mignet N. Combinaison de méthodes physiques et de méthodes de délivrance, RITS, Brest, Mai 2022
  5. Mignet N. Combination of drug delivery systems and physical trigger to provide drug release or immunomodulation, CRS Indian Chapter, February 2022

Brevets, licences et déclarations d’invention [2018-2022]

  1. Hang Korng EA, Vincent BOUDY, Amélie WOJCICKI, Sophie DUFAY. Alginate hydrogel and new composition derived therefrom for the treatment of ectopic calcifications. 2020-08-20 EP20305937.3; 2022-02-24 WO2022038213A1
  2. Pierre-Louis DESTRUEL, Vincent BOUDY, Ni ZENG, Nathalie MIGNET, Marc MAURY. Composition à base de gomme gellane et de phényléphrine, procédé de fabrication et utilisation comme produit ophtalmique. 2019-05-02 FRFR1904602; 2020-11-05 WO2020221839A1.
  3. Brice MARTIN, Nathalie MIGNET, Yohann CORVIS. Preparation of nanosuspension comprising nanocrystals of active pharmaceutical ingredients with little or no stabilising agents. 2018-08-27 EP18306138.1, 2020-03-05 WO2020043735A1.
  4. Yongmin ZHANG, Michel BESSODES, Johanne SEGUIN, Nathalie MIGNET, Daniel SCHERMAN. Agents d’imagerie optique ciblant une inflammation. 2018-02-21 EP18305183.8 ; 2019-08-29 WO2019162417A1.
  5. Hugo SALMON, Rabah GAHOUAL, Nathalie MIGNET, Pascal HOUZE. Dispositif microfluidique de fractionnement en continu à écoulement asymétrique et procédé d’utilisation correspondant 2018-02-22 EP 18305185.3, 2019-08-29 WO2019162404A1.
  6. Kathia LEMDANI, Johanne SEGUIN, Armand TIEDE DJIRO, Jean-Francois EMILE, Camille KURTZ, Nicolas LOMENIE. Procédé de détermination de l’infiltration de cellules biologiques dans un objet biologique. 2018-06-21 FR1855513A.
  7. Robert MALAFOSSE, Nathalie MIGNET, Vincent BOUDY, Johanne SEGUIN, Kathia LEMDANI, Claude CAPRON. Immunomodulation après un traitement antitumoral loco-régionale. 2016-08-31 EP16306102, 2018-03-08 WO2018041981A1
  8. Nathalie MIGNET, Bich-Thuy DOAN, Grégory RAMNICEANU, Olivier TILLEMENT, Lucie SANCEY GALLIOT, François LUX, Johanne SEGUIN. Nanoparticules ultrafines comme agent d’imagerie pour le diagnostic d’une dysfonction rénale. 2016-01-158, 2017-07-20 WO2017121858A1.
  9. Nathalie MIGNET, Vincent BOUDY, Johanne SEGUIN, Daniel SCHERMAN, Yoran BELDENGRUN. Compositions gélifiantes pour le traitement de tumeurs malignes et/ou la prévention de récidive de tumeur. 2015-09-166; 2017-03-23 WO2017046369A1.
  10. Stéphane AUVIN, Thomas STORME, Pascal VACONSIN, Vincent BOUDY. Formulation effervescente à base de pyridoxal-5-phosphate. 2015-06-30 FR1556142; 2017-01-05.
  11. Vincent BOUDY. Dispositif doseur de particules. 2013-07-17 FR1357012 ; 2015-01-22 WO2015008239A1.
  12. Vincent BOUDY, Annick TIBI, Benoît D’HAYER, Marie-Caroline HUSSON, Sandrine GRAFF DE FAGET ; Formulation gelifiante a base de ketamine. 2012-08-31 FR1258146, 2014-03-06 WO2014033680A1.
  13. Amanda BRUN-GRAEPPI, Daniel SCHERMAN, Michel BESSODES, Cyrille RICHARD, Otto MERTEN. Support pour la culture de cellules adhérentes et procédé pour leur détachement. 2012-08-17 EP 2698429 A1.
  14. Vincent BOUDY, Sandrine GRAFF DE FAGET, Caroline HUSSON, Imane BOUCENNA, Laurent ROYON, Pierre COLINART. Formulation gelifiante a base de gluconate de calcium. 2012-02-27 FR1251758, 2013-09-06 WO2013128383A1.

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