Dernières publications HAL
- [hal-03882629] Co-encapsulation of flavonoids with anti–cancer drugs : A challenge aheadpar ano.nymous@ccsd.cnrs.fr.invalid (Morgane Renault-Mahieux) le juillet 22, 2024
Flavonoids have been considered as promising molecules for cancer treatment due to their pleiotropic properties such as anti–carcinogenic, anti–angiogenic or efflux proteins inhibition. However, due to their lipophilic properties and their […]
- [hal-04626840] Radiofrequency Combined with Intratumoral Immunotherapy: Preclinical Results and Safety in Metastatic Colorectal...par ano.nymous@ccsd.cnrs.fr.invalid (Johanne Seguin) le juillet 17, 2024
Radiofrequency ablation (RFA) of cancer induces an anti-tumor immunity, which is insufficient to prevent recurrences. In mice, RFAu2013intratumoral immunotherapy by granulocyteu2013macrophage colony-stimulating factor (GM-CSF) and Bacillus […]
- [hal-04600227] Enhancing affinity purification of monoclonal antibodies from human serum for subsequent CZE-MS analysispar ano.nymous@ccsd.cnrs.fr.invalid (Tessa Reinert) le juin 4, 2024
Due to the separation technique employed, capillary electrophoresis coupled to mass spectrometry (CE-MS) analysis per-formances are significantly influenced by the chemical composition and the complexity of the sample. In various applica-tions, that […]
- [hal-04599782] Post-translational modifications comparative identification and kinetic study of infliximab innovator and...par ano.nymous@ccsd.cnrs.fr.invalid (Tessa Reinert) le juin 4, 2024
Despite reports indicating the potential impact of post-translational modifications on the activity of a monoclonal anti-body, their prediction or monitoring post-administration remains a challenge. In addition, with the expiration of patents […]
- [hal-04599685] Simultaneous quantification and structural characterization of monoclonal antibodies after administration using...par ano.nymous@ccsd.cnrs.fr.invalid (Tessa Reinert) le juin 4, 2024
Monoclonal antibodies (mAbs) are demonstrating major success in various therapeutic areas such as oncology and the treatment of immune disorders. Over the past two decades, novel analytical methodologies allowed to address the chal-lenges of mAbs […]
- [hal-04520002] mTOR Inhibition Impairs the Activation and Function of Belatacept-Resistant CD4+CD57+ T Cells In Vivo and In Vitropar ano.nymous@ccsd.cnrs.fr.invalid (Florence Herr) le mai 28, 2024
Calcineurin inhibitors have improved graft survival in solid-organ transplantation but their use is limited by toxicity, requiring a switch to another immunosuppressor in some cases. Belatacept is one option that has been shown to improve graft and […]
- [hal-04589406] Chromium-doped zinc gallate: Impact of Sn4+ co-doping on the persistent luminescence properties at the nanoscale...par ano.nymous@ccsd.cnrs.fr.invalid (Guanyu Cai) le mai 27, 2024
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- [hal-04576549] A methodological study for the diagnosis of the SARS-Cov-2 infection in human serum with a macrocyclic sensor arraypar ano.nymous@ccsd.cnrs.fr.invalid (Monica Bosco Swetha) le mai 15, 2024
This article reports the methodology and the proof of concept of a blood-based diagnostic strategy for the SARS-CoV-2 infection. The proposed method relies on the non-specific/selective array-based sensing strategy mimicking the human olfactory […]
- [hal-04490426] Long‐term outcome of paediatric anti‐N‐methyl‐D‐aspartate receptor...par ano.nymous@ccsd.cnrs.fr.invalid (Lorraine Flet‐berliac) le mars 6, 2024
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- [hal-04284754] Intracellular Delivery of Functional Proteins with DNA−Protein Nanogels−Lipids Complexpar ano.nymous@ccsd.cnrs.fr.invalid (Marina Mariconti) le février 19, 2024
Using functional proteins for therapeutic purposes due to their high selectivity and/or catalytic properties can enable the control of various cellular processes; however, the transport of active proteins inside living cells remains a major […]
- [hal-04387554] Impact of Fine Particles on a 3D Bronchial Healthy or Asthma Epithelium Model: Gene Expression Modulation...par ano.nymous@ccsd.cnrs.fr.invalid (Philomène Despréaux) le janvier 11, 2024
Environmental particles have dramatic consequences for health, especially for the most vulnerable people, such as asthmatics. To better understand the impact on gene expression modulation of fine particles (PM2.5-0.3) from different emission […]
- [hal-04381767] Obtaining two polymorphic forms of paracetamol within the phase diagram with PEG 1500par ano.nymous@ccsd.cnrs.fr.invalid (Maïlys Rassat) le janvier 9, 2024
Studies of the interactions between paracetamol, chosen as model active ingredient, and PEG 1500, a pharmaceutical carrier, are conducted in the solid state. Solid dispersions of PEG 1500 and paracetamol were prepared in different mass ratios. Two […]