Latest HAL publications

Microfluidics mixing is the current lab-scale method used for producing mRNA-loaded lipid nanoparticles (mRNA-LNPs) thanks to reproducibility and robustness of microfluidic mixing. Despite these advantages, the production of small LNP volumes is […]

Pancreatic ductal adenocarcinoma (PDAC) is among the most aggressive cancers, with a poor prognosis due to late diagnosis and resistance to chemotherapy. Gemcitabine (GEM) monotherapy was the gold standard treatment for PDAC until the early 2010s, […]

Pancreatic cancer is a lethal malignancy, frequently diagnosed at an advanced stage due to its asymptomatic progression. Current combinatorial therapies show the benefits of the multi-drug approach; however, the side effects of these therapeutic […]

Persistent luminescence (PersL) materials exhibit prolonged emission of light, lasting from seconds to hours after stopping the excitation. At the nanoscale, they have attracted considerable interest for applications in in vivo imaging, photodynamic […]

Les méthodes traditionnelles de construction de graphes de connaissances, manuelles et statiques, sont inadaptées aux domaines complexes et évolutifs. Bien que les grands modèles de langage permettent d'automatiser le processus, leurs […]

Plusieurs traitements médicamenteux sont aujourd'hui reconnus pour perturber l'équilibre complexe et bidirectionnel entre le microbiote intestinal et le système immunitaire de la muqueuse digestive. Il est désormais bien établi que les […]

Objective Liver injury includes inflammation and resolution stages with different macrophage populations. Hepatic macrophages can be imaged with ultrasmall paramagnetic iron oxide (USPIO) nanoparticles-enhanced magnetic resonance imaging (MRI). We […]

Using the PEP-scan approach, we have identified the binding site of PP2Ac to LRRK2, a protein associated with Parkinson's disease. We also have identified the binding site of LRRK2 to PP2Ac, referred to as mirror peptide. All isolated fragments are […]

Hepatic stellate cells (HSC) are known for their major role in hepatic fibrosis. It is well established that upon liver injury, they undergo a transition from a quiescent state to an activated state and transdifferentiate into proliferative, […]

Legal use of herbal health products must comply with quality and safety standards required by health regulatory authorities in order to protect consumers from risks associated with misidentification, falsification and undesirable toxic effects. Some […]

Immunogenic cell death (ICD), which converts tumor cells into their own vaccine, plays a pivotal role in the development of novel anticancer therapies. Here, a small series of osmium(II) polypyridyl complexes was synthesized, and their biological […]

PURPOSE: Immune checkpoint blockers (ICB) have revolutionized oncology by achieving durable tumor responses in advanced cancers. Nevertheless, currently approved biomarkers (PD-L1, microsatellite instability, and tumor mutational burden) have […]