Latest HAL publications

ABSTRACT Photodynamic therapy (PDT) is a promising, effective, and non‐invasive treatment for superficial cancers, utilizing reactive oxygen species (ROS) generated by induced light‐irradiated photosensitizers (PS) to provoke cancer cell death. […]

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All living beings use ribosomes to synthesize proteins from α-amino acids. Inherited from our common ancestor, a few universally conserved ribosome biogenesis steps, introducing essential ribosomal RNA modifications, have survived to our days. […]

Mitochondria are recognized as key players affecting hallmarks of oncogenesis, tumor progression, and chemotherapy resistance, positioning this organelle as an important therapeutic target. We previously demonstrated that impairment of the […]

Microfluidics mixing is the current lab-scale method used for producing mRNA-loaded lipid nanoparticles (mRNA-LNPs) thanks to reproducibility and robustness of microfluidic mixing. Despite these advantages, the production of small LNP volumes is […]

Pancreatic ductal adenocarcinoma (PDAC) is among the most aggressive cancers, with a poor prognosis due to late diagnosis and resistance to chemotherapy. Gemcitabine (GEM) monotherapy was the gold standard treatment for PDAC until the early 2010s, […]

Pancreatic cancer is a lethal malignancy, frequently diagnosed at an advanced stage due to its asymptomatic progression. Current combinatorial therapies show the benefits of the multi-drug approach; however, the side effects of these therapeutic […]

Persistent luminescence (PersL) materials exhibit prolonged emission of light, lasting from seconds to hours after stopping the excitation. At the nanoscale, they have attracted considerable interest for applications in in vivo imaging, photodynamic […]

Les méthodes traditionnelles de construction de graphes de connaissances, manuelles et statiques, sont inadaptées aux domaines complexes et évolutifs. Bien que les grands modèles de langage permettent d'automatiser le processus, leurs […]

Plusieurs traitements médicamenteux sont aujourd'hui reconnus pour perturber l'équilibre complexe et bidirectionnel entre le microbiote intestinal et le système immunitaire de la muqueuse digestive. Il est désormais bien établi que les […]

Objective Liver injury includes inflammation and resolution stages with different macrophage populations. Hepatic macrophages can be imaged with ultrasmall paramagnetic iron oxide (USPIO) nanoparticles-enhanced magnetic resonance imaging (MRI). We […]

Using the PEP-scan approach, we have identified the binding site of PP2Ac to LRRK2, a protein associated with Parkinson's disease. We also have identified the binding site of LRRK2 to PP2Ac, referred to as mirror peptide. All isolated fragments are […]