Latest HAL publications

Flavonoids have been considered as promising molecules for cancer treatment due to their pleiotropic properties such as anti–carcinogenic, anti–angiogenic or efflux proteins inhibition. However, due to their lipophilic properties and their […]

Radiofrequency ablation (RFA) of cancer induces an anti-tumor immunity, which is insufficient to prevent recurrences. In mice, RFAu2013intratumoral immunotherapy by granulocyteu2013macrophage colony-stimulating factor (GM-CSF) and Bacillus […]

Due to the separation technique employed, capillary electrophoresis coupled to mass spectrometry (CE-MS) analysis per-formances are significantly influenced by the chemical composition and the complexity of the sample. In various applica-tions, that […]

Despite reports indicating the potential impact of post-translational modifications on the activity of a monoclonal anti-body, their prediction or monitoring post-administration remains a challenge. In addition, with the expiration of patents […]

Monoclonal antibodies (mAbs) are demonstrating major success in various therapeutic areas such as oncology and the treatment of immune disorders. Over the past two decades, novel analytical methodologies allowed to address the chal-lenges of mAbs […]

Calcineurin inhibitors have improved graft survival in solid-organ transplantation but their use is limited by toxicity, requiring a switch to another immunosuppressor in some cases. Belatacept is one option that has been shown to improve graft and […]

[...]

This article reports the methodology and the proof of concept of a blood-based diagnostic strategy for the SARS-CoV-2 infection. The proposed method relies on the non-specific/selective array-based sensing strategy mimicking the human olfactory […]

[...]

Using functional proteins for therapeutic purposes due to their high selectivity and/or catalytic properties can enable the control of various cellular processes; however, the transport of active proteins inside living cells remains a major […]

Environmental particles have dramatic consequences for health, especially for the most vulnerable people, such as asthmatics. To better understand the impact on gene expression modulation of fine particles (PM2.5-0.3) from different emission […]

Studies of the interactions between paracetamol, chosen as model active ingredient, and PEG 1500, a pharmaceutical carrier, are conducted in the solid state. Solid dispersions of PEG 1500 and paracetamol were prepared in different mass ratios. Two […]