Imaging Platform LIOPA

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The Laboratory for Small Animal Optical Imaging (LIOPA) offers both optical imaging and MRI services for small animals (mice and rats). It comprises an imaging room and a housing room for rodents. This platform is part of the FLI (France Life Imaging) and IBiSA network of PIV platforms. The platform is dedicated to bimodal bioluminescence, fluorescence and micro-MRI imaging. Main applications include biodistribution of nano-medicines and tumor growth monitoring to visualize therapeutic effects.

Publications 2023-2024

2024

• Intraperitoneal administration of a thermogel combined with an anticancer agent for the prevention of peritoneal carcinomatosis in a pig model. Thouvenin A, Al Chirazi N, Seguin J, Crocheray C, Poupon J, Kaci R, Mignet N, Boudy V, Pocard M. Eur J Surg Oncol. 2024 Oct 28:108787. https://doi.org/10.1016/j.ejso.2024.108787.
• ZGSO:Cr3+,Ni2+ Persistent Phosphors with Dual Emission in NIR-I and SWIR Ranges for Bio-Imaging Applications. Cai G, Naillon T, Seguin J, Scherman D, Mignet N, Chaneac C, Richard C, Viana B. Small. 2024 Dec;20(51):e2406507. . https://doi.org/10.1002/smll.202406507.
• A Near-Infrared-Absorbing Osmium(II) Complex as a Photosensitizer for Photodynamic Therapy inducing Immunogenic Cell Death. Zhang Y, Mesdom P, Izquierdo-García E, António J, Saubamea B, Seguin J, et al. . ChemRxiv. 2024; . https://doi.org/10.26434/chemrxiv-2024-6dnl2 .
• Radiofrequency Combined with Intratumoral Immunotherapy: Preclinical Results and Safety in Metastatic Colorectal Carcinoma. Seguin J, El Hajjam M, Legagneux J, Diakhaby S, Mignet N, Boudy V, Toussaint B, Peschaud F, Emile JF, Capron C, Malafosse R. Pharmaceutics. 2024 Feb 23;16(3):315. https://doi.org/10.3390/pharmaceutics16030315.
• Wavelet-Based Sparse Non-Negative Matrix Factorization for Bioluminescent Imaging Unmixing.Erwan Dereure; Christophe Kervazo; Johanne Seguin; Anikitos Garofalakis; Nathalie Mignet; Elsa Angelini.2024 IEEE International Symposium on Biomedical Imaging (ISBI), Athens, Greece, 2024, pp. 1-5, https://doi.org/10.1109/ISBI56570.2024.10635436.
• Cai G, Naillon T, Seguin J, Scherman D, Mignet N, Chaneac C, Richard C, Viana B. ZGSO:Cr3+,Ni2+ Persistent Phosphors with Dual Emission in NIR-I and SWIR Ranges for Bio-Imaging Applications. Small. 2024 Dec;20(51):e2406507. https://doi.org/10.1002/smll.202406507.

2023

• Three in One: In Vitro and In Vivo Evaluation of Anticancer Activity of a Theranostic Agent that Combines Magnetic Resonance Imaging, Optical Bioimaging, and Photodynamic Therapy Capabilities. Boumati S, Sour A, Heitz V, Seguin J, Beitz G, Kaga Y, Jakubaszek M, Karges J, Gasser G, Mignet N, Doan BT. ACS Appl Bio Mater. 2023 Nov 20;6(11):4791-4804. https://doi.org/10.1021/acsabm.3c00565.
• Zwitterionic Functionalization of Persistent Luminescence Nanoparticles: Physicochemical Characterizations and In Vivo Biodistribution in Mice.  Dassonville, D.; Lécuyer, T.; Seguin, J.; Corvis, Y.; Liu, J.; Cai, G.; Mouton, J.; Scherman, D.; Mignet, N.; Richard, C.Coatings 2023, 13, 1913. https://doi.org/10.3390/coatings13111913 .
• In Situ Bioconjugation of a Maleimide-Functionalized Ruthenium-Based Photosensitizer to Albumin for Photodynamic Therapy. Vinck R, Dömötör O, Karges J, Jakubaszek M, Seguin J, Tharaud M, Guérineau V, Cariou K, Mignet N, Enyedy ÉA, Gasser G. Inorg Chem. 2023 Sep 25;62(38):15510-15526. . https://doi.org/10.1021/acs.inorgchem.3c01984 .
• M. Thai, G. Kalot, C. Venet, J. Seguin, M. Bocoum, N. Mignet, J. Gennisson, F. Ramaz, and A. Louchet-Chauvet, “Ultrasound Modulated Optical Tomography with Persistent Spectral Hole Burning Filter for In Vivo Deep Tissue Imaging,” in Conference on Lasers and Electro-Optics/Europe (CLEO/Europe 2023) and European Quantum Electronics Conference (EQEC 2023), Technical Digest Series (Optica Publishing Group, 2023), paper cl_2_3.
• Persistent Luminescence Induced by Upconversion: An Alternative Approach for Rechargeable Bio-Emitters. Luidgi Giordano, Guanyu Cai, Johanne Seguin, Jianhua Liu, Cyrille Richard, Lucas Carvalho Veloso Rodrigues, Bruno Viana. Advanced Optical Materials, 2023 11 (11), 2201468. https://doi-org.proxy.insermbiblio.inist.fr/10.1002/adom.202201468 .