Plateforme d’imagerie optique LIOPA

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Actualité

Ouverture d’un poste AI Mobilité Interne CNRS (FSEP) pour notre plateforme LIOPA ( affilié PIV imagerie du vivant université paris Cité )
Contacts : Nathalie Mignet Johanne Seguin
Fiche de poste Fiche de poste AI PF imagerie optique LIOPA

Team

Scientific leader : Bich-Thuy DOAN CR CNRS; bich-thuy.doan@chimieparistech.psl.eu

  • Expertise in MRI
  • Bimodal MRI/optical imaging
  • Image processing

 

 Technical expert : Johanne Seguin, IE, PhD CNRS; Johanne.seguin@u-paris.fr

  • Expertise in animal experimentation & optical imaging
  • Tumor models (implanted models, surgery)
  • Probe extraction
  • Data management & image processing

Équipement

Imaging of fluorescence and luminescence

  • 2 Photon Imager Biospace OPTIMA intensified CCD camera, X-ray signal superposition, 3D reconstruction, λ 400 to 800 nm, 5 mice
  • 1 Apogée Alta U 47 Macro lens, λ 250 -1050nm, large choice of filters
  • 1 Leica Z6 APO + apogee Alta U16 Macroscope Zoom 0.57-3.2 x , DAPI filter, Cy5, Rhodamine, GFP
  • 1 Fluobeam portable real-time imaging system, open system suitable for surgery, λex 690nm λem >700nm
  • 1 PRINCETON InGas camera imaging in the second window of tissue transparency for better laser resolution λex 808, 960nm λem >1064 -1600 nm

Ultrasound imaging-SWE

AIXplorer ultrasound with SL18-5 50mm probe (5-18 MHz, 256 elements), SLH2O-6 27mm probe (6- 20 MHz, 192 elements)

MRI imaging (Chemistry Paris)

Vertical RMN/ MRI Bruker 7 Tesla, Microimaging probes, ParaVision software

Photon Imager Biospace OPTIMA

Macroscope leica Z apo

Fluobeam portable real-time imaging system

mri

Main applications

  • Co-development and optimization of imaging agents (NIR I, NIR II & MRI)
  • Biodistribution of imaging agents (NIR I, NIR II & MRI)
  • Tumor growth monitoring
  • Evaluation of anti-tumor treatment

Associated services

  • Focused ultrasound
  • PDT Photodynamic therapy, PTT Photothermal therapy (520, 660, 700, 808 nm)
  • Radiofrequency
  • Electroporation
  • Magnetization
  • In vitro toxicity testing, stable lines BLI, FLI
  • Ex-vivo probe extraction and quantification, cell localization of the signal by cytometry and histology
  • Ultrasound /Elastography

 

Lung metastasis

Persistent luminescence nanoparticle

Tumor vascularisation

Contactez-nous

Publications 2021-2022

  • In vivo ultrasound modulated optical tomography with a persistent spectral hole burning filter. DOI: 10.1364/BOE.475449
  • Fate and biological impact of persistent luminescence nanoparticles after injection in mice: a one-year follow-up. DOI : 10.1039/D2NR03546D
  • Combination of thermal ablation by focused ultrasound pFAR4-IL-12 transfection and lipidic adjuvant provide a distal immune response. DOI : 10.37349/etat.2022.00090
  • Persistent luminescence nanoparticles functionalized by polymers bearing phosphonic acid anchors: synthesis, characterization, and in vivo behaviour. DOI 10.1039/D1NR07114A
  • Combination of tumor cell anti-adhesion and anti-tumor effect to prevent recurrence after cytoreductive surgery in a mice model. DOI : 10.1016/j.ejpb.2021.01.020
  • Co-Encapsulation of Fisetin and Cisplatin into Liposomes for Glioma Therapy: From Formulation to Cell Evaluation. DOI : 10.3390/pharmaceutics13070970
  • Antioxidant Activity and Toxicity Study of Cerium Oxide Nanoparticles Stabilized with Innovative Functional Copolymers. DOI : 10.1002/adhm.202100059

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