Genetic immunization
The aim of this project is to design mRNA vectorization strategies for vaccine applications against infectious diseases. The antigen against which the immune response is sought is encoded in the in vitro transcribed mRNA molecule (IVT-mRNA).
Schematic representation of a synthetic mRNA encoding a multi-epitope antigen
Vectorization strategies are required to give mRNA access to the cellular machinery, enabling in situ production of the antigen and the onset of the immune response against it. Unlike plasmid DNA, mRNA does not need to be transported to the nucleus, as it is translated in the cytoplasm. We intend to formulate mRNA-IVT molecules in our self-assembling nanoparticle vectors and administer them via different routes to assess the humoral and cellular immune response induced by expression of the mRNA-IVT-encoded antigen. Two vaccine applications are envisaged: (i) Immunization against Chagas disease in collaboration with Dr Alonso-Padillala and Pr Gascón, University of Barcelona, (ii) Immunization against gestational malaria in collaboration with Dr Ndam, MERIT laboratory “Mère et enfant avec infections tropicales”, IRD University of Paris.
Job offer : Two-year Postdoctoral Position. Project: FunkNano4Cancer – Functionalisation of nanoparticles for improved diagnostics and anti-cancer efficacy
Job offer : Two-year Postdoctoral Position. Project: FunkNano4Cancer – Functionalisation of nanoparticles for improved diagnostics and anti-cancer efficacy.
1st meeting on Lipid Nanoparticles for delivery
Nathalie Mignet and her team, in association with the Société Française de Nanomédecine, are organizing the 1st meeting on Lipid Nanoparticles for RNA delivery on Thursday April 3, 2025 at the Faculté de Pharmacie in Paris.
Nathalie Mignet, at the “advances in nanomedicine” international conference
The international conference “advances in nanomedicine” organized by the editorial office of the journal Precision Nanomedecine and the Kalinga Institute in Bhubaneswar, Odisha, India, brought together the leading names in nanomedicine, Lou Balogh, editor-in-chief of...
Sarah Diakhaby, at the 6th International Cancer Symposium of the CRCL
Sarah Diakhaby shared part of her PhD work during the 6th International Cancer Symposium of the CRCL.