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Poloxamer-based thermosensitive hydrogels were developed in close partnership with Ageps (V. Boudy) and the Faculty of Pharmacy (N. Mignet, J. Seguin, UTCBS), with hospital collaborators from Hôpital Lariboisière (Dr. M. Pocard) and Ambroise Paré (Dr. R. Malafosse). The design of mucoadhesive gelling formulations was achieved by combining physico-chemical methods (rheology) and imaging methods in small animals to determine the residence times of hydrogels and/or active ingredients, or to determine therapeutic effects. We were thus able to show that we could prolong the lifetime of APIs in the buccal mucosa of rabbits (10.1016/j.ijpharm.2017.09.073, Figure 1), that we could obtain adjuvant and neoadjuvant effects by delivering cytotoxic APIs into tumors (10.1016/j.ejpb.2020 .10.011, Figure 2), and more recently that we could stimulate the immune response in situ, leading to an abscopal effect (10.1080/2162402X.2018.1550342). These formulations have also been optimized for ocular delivery of active ingredients (10.1016/j.ijpharm.2019.118734; 10.3390/pharmaceutics12040360, Figure 3). Nanometric, non-cationic, gel-core formulations have also been used to encapsulate and deliver interfering RNAs (10.3390/pharmaceutics13040479; 10.3390/pharmaceutics1304047).

Oral route:

Fig. In vitro and in vivo validation of heat-sensitive gels for buccal drug delivery in vitro

Influence of additives on a thermosensitive hydrogel for buccal delivery of salbutamol: relation between micellization, gelation, mechanic and release properties 10.1016/j.ijpharm.2014.03.055
Poloxamer bioadhesive hydrogel for buccal drug delivery: Cytotoxicity and trans-epithelial permeability evaluations using TR146 human buccal epithelial cell line 10.1016/j.ijpharm.2015.09.045
Cyanine derivative as a suitable marker for thermosensitive in situ gelling delivery systems: In vitro and in vivo validation of a sustained buccal drug delivery 10.1016/j.ijpharm.2017.09.073

Application in cancer :

Fig.2  : Heat-sensitive hydrogels for local administration of 5-fluorouracil as neoadjuvant or adjuvant therapy in colorectal cancer

Local immunomodulation combined to radiofrequency ablation results in a complete cure of local and distant colorectal carcinoma ; 10.1080/2162402X.2018.1550342
Combination of tumor cell anti-adhesion and anti-tumor effect to prevent recurrence after cytoreductive surgery in a mice model ; 10.1016/j.ejpb.2021.01.020
Thermosensitive hydrogels for local delivery of 5-fluorouracil as neoadjuvant or adjuvant therapy in colorectal cancer ; 10.1016/j.ejpb.2020.10.011

Ocular route :

Fig. 3 : Advantages of the liquid and gel phases of in situ gelled ophthalmic delivery systems

In vitro and in vivo evaluation of in situ gelling systems for sustained topical ophthalmic delivery: state of the art and beyond : 10.1016/j.drudis.2016.12.008
Novel in situ gelling ophthalmic drug delivery system based on gellan gum and hydroxyethylcellulose: Innovative rheological characterization, in vitro and in vivo evidence of a sustained precorneal retention time  10.1016/j.ijpharm.2019.118734
In Situ Gelling Ophthalmic Drug Delivery System for the Optimization of Diagnostic and Preoperative Mydriasis: In Vitro Drug Release, Cytotoxicity and Mydriasis Pharmacodynamics 10.3390/pharmaceutics12040360

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