Latest HAL publications

Introduction : la dégénérescence maculaire liée à l'âge (DMLA) est une maladie rétinienne cécitante où la dysrégulation du stress oxydatif joue un rôle majeur. L'étude AREDS (Age-Related Eye Disease Study), vaste essai clinique […]

Nanocrystals have emerged as an interesting class of delivery systems for solubilizing pharmaceuticals in classes II and IV of the Biopharmaceutics Classification System (BCS) † . This can be attributed to their small size and high drug content. […]

Chromium-doped zinc gallate (ZnGa2O4:Cr3 +) nanoparticles (ZGO) show promising potential for antigen immunodetection using persistent luminescence, thereby reducing autofluorescence interference. Recently, we have shown that ZGO prepared by […]

<div><p>Pancreatic ductal adenocarcinoma is an aggressive and often fatal cancer, primarily due to its insidious progression and the lack of effective screening tools, which frequently result in late-stage diagnosis 1 . For many years, […]

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Gemcitabine is a commonly used chemotherapeutic agent that faces limitations due to rapid clearance, limited stability, and significant adverse effects. Recent efforts in its nanoencapsulation within Metal Organic Frameworks (MOFs) aim to overcome […]

Hepatocellular carcinoma is one of the most frequent cancers in the world. Treatments such as immune checkpoint inhibitors or tyrosine kinase inhibitors (TKI) have some efficacy but have many adverse effects. So, more specifically targeted therapies […]

<div><p>Parkinson's disease (PD) is a complex neurodegenerative disorder for which there is presently only palliative treatments. Recently, the interaction between the Leucine Reach Repeat Kinase 2 (LRRK2) and the Protein Phosphatase 1 […]

Introduction: Nucleic acid-based therapies are promising advancements in medicine. They offer unparalleled efficacy in treating previously untreatable diseases through precise gene manipulation techniques. However, the challenge of achieving […]

Summary Hepatic stellate cells (HSC) are known for their major role in hepatic fibrosis. Recently, it has been shown that different subpopulations of HSC co-exist during fibrogenesis and play different roles in the establishment of fibrosis. We […]

La présente invention concerne un composé de formule (I) dans laquelle n = 1 ou 2, A et A' sont indépendamment choisi dans le groupe constitué des substituants (ll-a) et (ll-b), R et R' étant indépendamment choisis parmi H et les alkyles […]