Latest HAL publications
- [hal-04954331] Clinical, biological, metabolic and immune changes associated with the use of Sodium-glucose cotransporter 2...by ano.nymous@ccsd.cnrs.fr.invalid (Vincent Guiraud) on 18 February 2025
Introduction : Positive cardiovascular and renal outcomes associated with the Sodium-Glucose cotransporter 2 inhibitor (SGLT2i) use are attributed to their anti-inflammatory properties. Persistent immune activation accounts for part of people living […]
- [hal-04945679] Binary phase diagrams between ascorbic acid and PEG 1500, 4000 and 6000by ano.nymous@ccsd.cnrs.fr.invalid (Elena Losi) on 13 February 2025
Solid dispersions of ascorbic acid in 3 different PEG matrices, PEG 1500, 4000 and 6000 were studied by thermal analyzes and X-ray diffraction. Vitamin C was mixed in different mass proportions with each of the PEGs, thus making it possible to […]
- [tel-04938353] Elaboration of pharmaceutical interest nanosized crystals for bioavailability improvement of drugsby ano.nymous@ccsd.cnrs.fr.invalid (Panpan Ma) on 10 February 2025
In this study, nanocrystalline suspensions (NCs) of Fisetin and Curcumin and a combination of etoposide (ETO) and prednisolone (PRD) were developed for potential applications in nanomedicine. The NCs demonstrated excellent characteristics, including […]
- [hal-04934942] Sialyl Lewis X (sLex):Biological functions, synthetic methods and therapeutic implicationsby ano.nymous@ccsd.cnrs.fr.invalid (Leyu Tang) on 7 February 2025
Carbohydrates are shown to be crucial to several biological processes. They are essential mediators of cell-cell recognition processes. Among them, Sialyl Lewis X (sLe x ) is a very significant structure in the human body. It is a critical […]
- [hal-04888066] Correcting Autoinflammation in STING-Associated Vasculopathy with Onset in Infancy (SAVI) by Human Stem Cell...by ano.nymous@ccsd.cnrs.fr.invalid (Sebastien Viel) on 15 January 2025
Abstract Type I interferonopathies comprise a large group of Mendelian autoinflammatory diseases that generally lack effective treatments. STING-associated Vasculitis with onset in Infancy (SAVI) is a severe autosomal dominant disease due to […]
- [tel-04873486] Fingerprint approach using macrocyclic chemical nose sensors for disease diagnosticsby ano.nymous@ccsd.cnrs.fr.invalid (Monica Swetha Bosco) on 8 January 2025
The biomolecular compositions of body fluids reflect the severity and progression of diseases, offering valuable diagnostic insights. This thesis investigates a non-specific, hypothesis-free, serum-based "chemical nose" approach, inspired by the […]
- [hal-04837139] Design of new nano-tools to target mitochondria and study the metabolic plasticity of cancer cellsby ano.nymous@ccsd.cnrs.fr.invalid (Dorna Akbarzadeh) on 17 December 2024
Metabolic plasticity and mitochondrial function are crucial in tumorigenesis and cancer therapy response, making mitochondria a key target for novel treatments (1-2). Bioactive molecules, modulating mitochondrial activity, offer alternative […]
- [hal-04831942] MULTIFUNCTIONAL NANOPARTICLES TO FIGHT HORMONE-RESISTANT PROSTATE CANCERby ano.nymous@ccsd.cnrs.fr.invalid (Killian Laguerre) on 11 December 2024
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- [hal-04790449] NANOPARTICLE FOR THE DETECTION OF H 20 2by ano.nymous@ccsd.cnrs.fr.invalid (Cyrille Richard) on 19 November 2024
<div xmlns="http://www.tei-c.org/ns/1.0"><head>Field of the invention</head><p>The present invention relates to a method for the detection of H2O2 in a sample comprising a persistent luminescence […]
- [hal-04790380] Improvement of Hydrogen Peroxide and Glucose Detection in Serum using Persistent Luminescent Nanoparticles: Impact...by ano.nymous@ccsd.cnrs.fr.invalid (Zied Ferjaoui) on 19 November 2024
Persistent Luminescent Nanoparticles (PLNPs) emit prolonged light after excitation, allowing getting images with high signal‐to‐noise ratio, making them particularly beneficial for in vitro biodetection. In this study, we report the […]
- [hal-04758748] Combination of designed liposomes and sonoporation provide drug release or immunomodulationby ano.nymous@ccsd.cnrs.fr.invalid (Bich-Thuy Doan) on 29 October 2024
Liposomes are extremely interesting to overcome some limitations of drugs, such as cytotoxicity, however, sometimes, liposomes are not sufficient by themselves to overcome the complexity of the environment, in particular in cancer, where the […]
- [hal-04758692] Nanocrystals as novel nanomedicines in cancerby ano.nymous@ccsd.cnrs.fr.invalid (Nathalie Mignet) on 29 October 2024
Nanomedicine represents alternative solutions to treat patients with cancer limiting toxicity to certain organs related to large systemic amount of drug and providing better accumulation in vascularized tumors. Despite the encapsulation of drugs […]