Latest HAL publications

Liposomes are extremely interesting to overcome some limitations of drugs, such as cytotoxicity, however, sometimes, liposomes are not sufficient by themselves to overcome the complexity of the environment, in particular in cancer, where the […]

Nanomedicine represents alternative solutions to treat patients with cancer limiting toxicity to certain organs related to large systemic amount of drug and providing better accumulation in vascularized tumors. Despite the encapsulation of drugs […]

Albumin is a common endogenous protein which is relatively easy to chemically modify. In the past, we were interested in targeting asialoglycoprotein receptors to evaluate the liver function. Using SPECT1 and optical imaging2, we observed a fast […]

Context Cancer immunotherapy in combination with nanomedicine is of high interest to achieve a systemic immune response. Additional physical methods can bring the specificity related to immunogenic cell death. In the literature, interleukin-12 […]

The tyrosine kinase Inhibitor (TKI) imatinib is approved for the treatment of the chronic phase of chronic myeloid leukemia (CP-CML). Pharmacokinetic studies have highlighted the importance of inter-patient variability on imatinib plasma trough […]

<div><p>Persistent luminescence (PersL) nanoparticles emit a signal that lasts long after the excitation has ended, enabling highly sensitive bioimaging without background noise. When using UV light as excitation source before the […]

<div><p>PEP-010 is a pro-apoptotic peptide based on a proprietary cell-penetrating and interfering peptide technology for the treatment of advanced solid tumors.</p><p>• PEP-010 acts by disrupting the interaction between […]

<div><p>Depuis une quinzaine d'années, de nombreuses études cherchent à identifier le rôle de la phospholipase A2 associée aux lipoprotéines (Lp-PLA2) dans les pathologies ayant une composante d'inflammation vasculaire, parmi […]

The encapsulation of molecules with different physicochemical properties (theophylline, blue dextran, salicylic acid and insulin) in whey protein (WP) and alginate (ALG) microparticles (MP) for oral administration was studied. MP based on WP/ALG […]

Radiofrequency ablation (RFA) of cancer induces an anti-tumor immunity, which is insufficient to prevent recurrences. In mice, RFAu2013intratumoral immunotherapy by granulocyteu2013macrophage colony-stimulating factor (GM-CSF) and Bacillus […]

Due to the separation technique employed, capillary electrophoresis coupled to mass spectrometry (CE-MS) analysis per-formances are significantly influenced by the chemical composition and the complexity of the sample. In various applica-tions, that […]

Despite reports indicating the potential impact of post-translational modifications on the activity of a monoclonal anti-body, their prediction or monitoring post-administration remains a challenge. In addition, with the expiration of patents […]