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Penetrating and interfering peptides for the treatment of cancer
This project is based on the modeling, characterization and development of new therapeutic tools for the treatment of cancers, pathologies requiring the development of specific therapies without side effects.
To this end, we are using the approach of penetrating peptides and tumor interfering peptides (TP and IP), capable of specifically penetrating the tumor cell, with no effect on healthy cells, and blocking the interaction between two proteins deregulated during tumor transformation. We are also developing organelle-specific penetrating peptides focusing on the nucleus and mitochondria.
The cell-penetrating and cell-interfering peptide approach has great relevance in medicine, with over 240 therapeutic peptides currently being tested in clinical trials. What’s more, a large number have already been approved for the treatment of several pathologies. This project is highly relevant to the field of oncology, and original in terms of the approach used to identify protein-protein interactions and optimize drug candidates.
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Also to be read
CNRS honors Néovacs and UTCBS, united for a therapeutic RNA vaccine against asthma
Suresnes, August 29, 2024 - 8am CET - Neovacs (Euronext Growth Paris : ALNEV), a preclinical-stage biopharmaceutical company developing novel therapies for inflammatory and autoimmune diseases, is honored to be listed among the latest CNRS publications following the...
Publication in Advanced Science of Preclinical tests obtained with a pFAR plasmid
Gene Electrotransfer via Conductivity-Clamped Electric Field Focusing Pivots Sensori-Motor DNA Therapeutics: “A Spoonful of Sugar Helps the Medicine Go Down” https://doi.org/10.1002/advs.202401392
Khair Alareth, Caroline Roques and Nasir Arafath with Nathalie Mignet to present UTCBS’s work at the Controlled release society international congress in Bologna.
UTCBS presents its work at the international congress of the "controlled release society" in Bologna. The UTCBS team has shown the interest of nanoparticles both for the imaging of ROS in vivo and the promotion of antioxydant therapeutic activity. Caroline Roques...
The Alnylam Pharmaceuticals 2024 “Interfering RNA & Rare Diseases” Prize has been awarded to Virginie Escriou,
The Alnylam Pharmaceuticals 2024 “Interfering RNA & Rare Diseases” Prize has been awarded to Virginie Escriou,