Compression of siRNA vectors for oral administration
Oral administration is currently the most widely used route of drug delivery, due to its ease of use combined with good patient compliance. However, the routes of administration of vectorized nucleic acids are most often local or by intravenous injection. Thus, a formulation designed for oral administration of siRNA would have significant potential for the development of new therapies.
Tablets of siRNA lipoplexes, with a diameter of 6 mm obtained under a compaction pressure of 150 MPa.
This project is being carried out in collaboration with Professor Tchoreloff’s team (CNRS UMR 5295 Bordeaux). We have shown that it is possible to formulate siRNA vectors into tablets while preserving the gene silencing efficiency of the particle, and have filed a patent describing this process. We then showed that, when administered orally to rodents with dextran sulfate-induced ulcerative colitis, siRNA vectors in compressed form were able to specifically inhibit the target gene, in this case that of the cytokine TNF-α. These results pave the way for the administration of siRNA vectors in dry form.
Brevet FR 17 54105 PCT 2018 WO2018206723A1
Read the article “les comprimés de lipoplexes de siRNA”
UTCBS takes part in sfnano2024 conference
UTCBS takes part in sfnano2024 conference
Thesis defense at UTCBS: Monica Swetha Bosco “Fingerprint Approach Using Macrocyclic Chemical Nose Sensors for Disease Diagnostics”
Thesis defense at UTCBS: Monica Swetha Bosco “Fingerprint Approach Using Macrocyclic Chemical Nose Sensors for Disease Diagnostics”
Thesis defense at UTCBS: Nasir Arafath “Functionalization and Evaluation of Antioxidant Cerium Oxide Nanoparticles for Stroke Treatment.
Thesis defense at UTCBS: Nasir Arafath
For the 2nd year running, UTCBS is hosting a delegation of South African researchers as part of a bilateral PHC
For the 2nd year running, UTCBS is hosting a delegation of South African researchers as part of a bilateral PHC