Compression of siRNA vectors for oral administration
Oral administration is currently the most widely used route of drug delivery, due to its ease of use combined with good patient compliance. However, the routes of administration of vectorized nucleic acids are most often local or by intravenous injection. Thus, a formulation designed for oral administration of siRNA would have significant potential for the development of new therapies.
Tablets of siRNA lipoplexes, with a diameter of 6 mm obtained under a compaction pressure of 150 MPa.
This project is being carried out in collaboration with Professor Tchoreloff’s team (CNRS UMR 5295 Bordeaux). We have shown that it is possible to formulate siRNA vectors into tablets while preserving the gene silencing efficiency of the particle, and have filed a patent describing this process. We then showed that, when administered orally to rodents with dextran sulfate-induced ulcerative colitis, siRNA vectors in compressed form were able to specifically inhibit the target gene, in this case that of the cytokine TNF-α. These results pave the way for the administration of siRNA vectors in dry form.
Brevet FR 17 54105 PCT 2018 WO2018206723A1
Read the article “les comprimés de lipoplexes de siRNA”
Job offer : Two-year Postdoctoral Position. Project: FunkNano4Cancer – Functionalisation of nanoparticles for improved diagnostics and anti-cancer efficacy
Job offer : Two-year Postdoctoral Position. Project: FunkNano4Cancer – Functionalisation of nanoparticles for improved diagnostics and anti-cancer efficacy.
1st meeting on Lipid Nanoparticles for delivery
Nathalie Mignet and her team, in association with the Société Française de Nanomédecine, are organizing the 1st meeting on Lipid Nanoparticles for RNA delivery on Thursday April 3, 2025 at the Faculté de Pharmacie in Paris.
Nathalie Mignet, at the “advances in nanomedicine” international conference
The international conference “advances in nanomedicine” organized by the editorial office of the journal Precision Nanomedecine and the Kalinga Institute in Bhubaneswar, Odisha, India, brought together the leading names in nanomedicine, Lou Balogh, editor-in-chief of...
Sarah Diakhaby, at the 6th International Cancer Symposium of the CRCL
Sarah Diakhaby shared part of her PhD work during the 6th International Cancer Symposium of the CRCL.