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Penetrating and interfering peptides for the treatment of cancer

This project is based on the modeling, characterization and development of new therapeutic tools for the treatment of cancers, pathologies requiring the development of specific therapies without side effects.
Scheme of action of penetrating peptides

To this end, we are using the approach of penetrating peptides and tumor interfering peptides (TP and IP), capable of specifically penetrating the tumor cell, with no effect on healthy cells, and blocking the interaction between two proteins deregulated during tumor transformation. We are also developing organelle-specific penetrating peptides focusing on the nucleus and mitochondria.

The cell-penetrating and cell-interfering peptide approach has great relevance in medicine, with over 240 therapeutic peptides currently being tested in clinical trials. What’s more, a large number have already been approved for the treatment of several pathologies. This project is highly relevant to the field of oncology, and original in terms of the approach used to identify protein-protein interactions and optimize drug candidates.

This project is developed by the Dr Angélita REBOLLO.

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