Compression of siRNA vectors for oral administration
Oral administration is currently the most widely used route of drug delivery, due to its ease of use combined with good patient compliance. However, the routes of administration of vectorized nucleic acids are most often local or by intravenous injection. Thus, a formulation designed for oral administration of siRNA would have significant potential for the development of new therapies.
Tablets of siRNA lipoplexes, with a diameter of 6 mm obtained under a compaction pressure of 150 MPa.
This project is being carried out in collaboration with Professor Tchoreloff’s team (CNRS UMR 5295 Bordeaux). We have shown that it is possible to formulate siRNA vectors into tablets while preserving the gene silencing efficiency of the particle, and have filed a patent describing this process. We then showed that, when administered orally to rodents with dextran sulfate-induced ulcerative colitis, siRNA vectors in compressed form were able to specifically inhibit the target gene, in this case that of the cytokine TNF-α. These results pave the way for the administration of siRNA vectors in dry form.
Brevet FR 17 54105 PCT 2018 WO2018206723A1
Read the article “les comprimés de lipoplexes de siRNA”
For the 2nd year running, UTCBS is hosting a delegation of South African researchers as part of a bilateral PHC
For the 2nd year running, UTCBS is hosting a delegation of South African researchers as part of a bilateral PHC
CNRS honors Néovacs and UTCBS, united for a therapeutic RNA vaccine against asthma
Suresnes, August 29, 2024 - 8am CET - Neovacs (Euronext Growth Paris : ALNEV), a preclinical-stage biopharmaceutical company developing novel therapies for inflammatory and autoimmune diseases, is honored to be listed among the latest CNRS publications following the...
Publication in Advanced Science of Preclinical tests obtained with a pFAR plasmid
Gene Electrotransfer via Conductivity-Clamped Electric Field Focusing Pivots Sensori-Motor DNA Therapeutics: “A Spoonful of Sugar Helps the Medicine Go Down” https://doi.org/10.1002/advs.202401392
Khair Alareth, Caroline Roques and Nasir Arafath with Nathalie Mignet to present UTCBS’s work at the Controlled release society international congress in Bologna.
UTCBS presents its work at the international congress of the "controlled release society" in Bologna. The UTCBS team has shown the interest of nanoparticles both for the imaging of ROS in vivo and the promotion of antioxydant therapeutic activity. Caroline Roques...