Monica Swetha Bosco successfully defended her doctoral thesis, titled “Fingerprint Approach Using Macrocyclic Chemical Nose Sensors for Disease Diagnostics,” under the supervision of Dr. Nathalie Gagey-Eilstein. She presented her findings to a jury comprising Dr. Clémence Allain, Dr. Arnaud Gautier, Dr. William Peveler, Dr. Benoit Colasson, and Dr. Florence Mahuteau-Betzer. Her research focuses on the development of chemical sensors inspired by the human olfactory system, utilizing the host-guest interactions between the macrocyclic host family of cucurbit[n]urils (CB[n]) and multibranched conjugated triphenylamine (TPA) guest derivatives to produce optical fingerprints with interacting analytes. These developed array-based sensors have been applied to disease diagnostics applications, particularly in the fingerprinting of body fluids for disease models such as phenylketonuria and preeclampsia.
